A prospective study proposing an anatomical score to predict gross-total resection in recurrent pituitary neuroendocrine tumors.

Zohney, Abd Elshafouk, Aziz, Ismail and El-Bahy evaluated 32 patients undergoing endoscopic endonasal reoperation. The proposed score incorporates tumor size, morphology, cavernous sinus invasion and extrasellar extension.

Gross-total resection was achieved in 91% of class I tumors and 57% of class II tumors, while no gross-total resections were achieved in classes III–IV. The score remains preliminary and requires external validation.

Why it matters

Recurrent PitNETs are often substantially more difficult than primary tumors. A structured anatomical score may help with preoperative counseling, operative planning and realistic assessment of resectability, particularly in revision endoscopic surgery.

Reference

Zohney M, Abd Elshafouk MH, Aziz MM, Ismail MAM, El-Bahy K.
Recurrent Pituitary Neuroendocrine Tumors: Anatomical Predictors of Gross-Total Resection with a Proposed Pituitary Resectability Score.
World Neurosurgery. Published September 28, 2026.
DOI: 10.1016/j.wneu.2026.125377
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